It was bound to happen — there’s a significant fantasy injury less than a week into training camp.

San Francisco running back Frank Gore broke a bone in his right hand Monday. He might not play in the preseason, though he will practice with a cast and is expected to be ready for the regular season.

The injury itself isn’t so significant as the player who suffered it — Gore is a top-five running back. His draft stock drops a little, not much in my opinion, but behind Rudi Johnson and Shaun Alexander as the No. 6 RB on the board. My drop reflects that he might be little rusty the first few weeks, plus who knows how well he’ll be holding the ball those opening games (a concern especially if you are in a league that penalizes for fumbles). He should still be the 49ers’ workhorse and probably will be back to form come October. If his hand heals quicker than expected, I’ll move him back past Johnson and Alexander. As with many preseason injuries, his progress in the coming weeks will affect his draft position.